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May PRP Assist Lower Danger of Rotator Cuff Reinjury?

Platelet-rich plasma doesn’t enhance medical leads to sufferers with rotator cuff problems however reduces the retear price. A scientific overview and meta-analysis

Feltri P, Gonalba GC, Boffa A, Candrian C, Menon A, Randelli PS, Filardo G. Knee Surg Sports activities Traumatol Arthrosc. 2022 Dec 11. doi: 10.1007/s00167-022-07223-9. Epub forward of print. PMID: 36496450.

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Take-House Message

Together with platelet-rich plasma (PRP) with a rotator cuff surgical procedure decreased retear price in comparison with surgical procedure with out PRP. Nevertheless, PRP had no different clear medical advantages throughout conservative or surgical therapy.


Rotator cuff accidents are widespread accidents that may be handled with quite a few conservative or surgical therapy choices; nonetheless, these choices will not be at all times efficient and can lead to persistent signs or retear. Platelet-rich plasma (PRP) has gained curiosity attributable to its excessive focus of proteins concerned within the therapeutic course of and its low price of antagonistic results. There’s blended proof relating to PRP’s efficacy in decreasing ache, growing operate, and lowering the chance of retear. Therefore, a scientific overview might assist make clear PRP’s function in treating individuals with rotator cuff problems.

Examine Aim

The authors carried out a scientific overview and meta-analysis to judge the efficacy of PRP by way of useful enchancment, ache discount, and retear price following conservative or surgical therapy of rotator cuff problems.


An preliminary database search yielded 1,229 articles, and the authors then recognized 36 eligible medical trials for the systematic overview. The authors then used 18 of these trials for the meta-analysis. The inclusion standards required a randomized trial (printed in English) to incorporate particular outcomes (useful scores, ache scores, and retear price) and the usage of PRP amongst individuals receiving conservative or surgical therapy of a rotator cuff dysfunction. The authors extracted 1) publication data (e.g., authors, journal), 2) inhabitants traits (age, intercourse, sort of lesion, tendon concerned), 3) tear traits (sort of lesion, tendon(s) concerned), 4) PRP traits, 5) restore approach (if relevant), 5) comply with up [split into short term (<6.5 months) and long term (>12 months)], and 6) medical outcomes.


The 36 medical trials included 2,443 individuals (~49% feminine, ~54 years of age, ~16 months comply with up). Of the 36 randomized management trial articles, 16 examined PRP inside the context of conservative therapy, and 20 examined PRP inside the context of surgical therapy. The authors couldn’t do a  meta-analysis among the many trials with conservative administration as a result of they different an excessive amount of in outcomes, variety of PRP injections, PRP quantity used, and various therapies supplied (e.g., corticosteroids, saline, train, or bodily remedy). Typically talking, PRP had blended outcomes with ache and performance in comparison with different conservative therapies. Nineteen of the 20 surgical research have been included within the meta-analysis. The authors discovered no variations in self-reported ache or operate between individuals receiving surgical procedure with or with out PRP. The sufferers that acquired PRP and surgical procedure had a retear price of ~7%, whereas the management group had a retear price of ~14%.


PRP could also be an efficient therapy with rotator cuff surgical procedure to cut back the chance of a retear in contrast with surgical procedure with out PRP. Curiously, the PRP failed to supply higher self-reported ache or capabilities than surgical procedure alone. Sadly, it stays unclear whether or not PRP decreases ache and will increase operate in conservatively managed individuals. When a clinician appears on the numerous trials amongst individuals conservatively managed, the clinician wants to contemplate what the opposite therapy group acquired, the PRP protocol, and the follow-up visits. Clinicians ought to concentrate on the trials that replicate their PRP protocol (or what they will provide) and affected person inhabitants in addition to contemplate whether or not they need to see how their outcomes evaluate to ordinary care, placebo, or an energetic intervention (e.g., corticosteroid). Lastly, it’s price remembering to concentrate on variations between teams in a medical trial. This comparability is the one one which takes benefit of why we need to randomize individuals into completely different teams. Outcomes that look at modifications over time inside a bunch could also be influenced by placebo results, regression to the imply, or different elements unrelated to the therapy.

Scientific Implications

The usage of PRP may lower the chance of retear if carried out together with surgical procedure. If a affected person is receiving conservative administration, clinicians can search for particular research that simulate their observe and therapy targets to assist sufferers resolve. Nevertheless, sufferers receiving conservative care must also perceive that the proof for PRP is murky, however the threat of antagonistic occasions is low.   

Questions for Dialogue

Have any of your sufferers acquired PRP injections? In that case, what have been their ideas? Would you employ or advocate PRP remedy?

Associated Posts

  1. Frequent Medicines Might Influence PRP Efficacy
  2. The Optimistic Results of Totally different Platelet-Wealthy Plasma Strategies on Human Muscle, Bone, and Tendon Cells
  3. Platelet-Wealthy Plasma Falls Quick In contrast with Train Remedy

Written by Jane McDevitt
Reviewed by Jeffrey Driban

Upper Extremity EBP CEU Course

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