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Might PRP Assist Lower Danger of Rotator Cuff Reinjury?

Platelet-rich plasma doesn’t enhance scientific leads to sufferers with rotator cuff issues however reduces the retear charge. A scientific assessment and meta-analysis

Feltri P, Gonalba GC, Boffa A, Candrian C, Menon A, Randelli PS, Filardo G. Knee Surg Sports activities Traumatol Arthrosc. 2022 Dec 11. doi: 10.1007/s00167-022-07223-9. Epub forward of print. PMID: 36496450.

Full Textual content Freely Obtainable

Take-Residence Message

Together with platelet-rich plasma (PRP) with a rotator cuff surgical procedure decreased retear charge in comparison with surgical procedure with out PRP. Nevertheless, PRP had no different clear scientific advantages throughout conservative or surgical remedy.


Rotator cuff accidents are frequent accidents that may be handled with quite a few conservative or surgical remedy choices; nonetheless, these choices usually are not all the time efficient and may end up in persistent signs or retear. Platelet-rich plasma (PRP) has gained curiosity attributable to its excessive focus of proteins concerned within the therapeutic course of and its low charge of antagonistic results. There may be combined proof relating to PRP’s efficacy in decreasing ache, growing operate, and lowering the chance of retear. Therefore, a scientific assessment could assist make clear PRP’s function in treating folks with rotator cuff issues.

Research Purpose

The authors carried out a scientific assessment and meta-analysis to judge the efficacy of PRP when it comes to purposeful enchancment, ache discount, and retear charge following conservative or surgical remedy of rotator cuff issues.


An preliminary database search yielded 1,229 articles, and the authors then recognized 36 eligible scientific trials for the systematic assessment. The authors then used 18 of these trials for the meta-analysis. The inclusion standards required a randomized trial (revealed in English) to incorporate particular outcomes (purposeful scores, ache scores, and retear charge) and using PRP amongst folks receiving conservative or surgical remedy of a rotator cuff dysfunction. The authors extracted 1) publication data (e.g., authors, journal), 2) inhabitants traits (age, intercourse, sort of lesion, tendon concerned), 3) tear traits (sort of lesion, tendon(s) concerned), 4) PRP traits, 5) restore approach (if relevant), 5) observe up [split into short term (<6.5 months) and long term (>12 months)], and 6) scientific outcomes.


The 36 scientific trials included 2,443 members (~49% feminine, ~54 years of age, ~16 months observe up). Of the 36 randomized management trial articles, 16 examined PRP throughout the context of conservative remedy, and 20 examined PRP throughout the context of surgical remedy. The authors couldn’t do a  meta-analysis among the many trials with conservative administration as a result of they diversified an excessive amount of in outcomes, variety of PRP injections, PRP quantity used, and different therapies supplied (e.g., corticosteroids, saline, train, or bodily remedy). Usually talking, PRP had combined outcomes with ache and performance in comparison with different conservative therapies. Nineteen of the 20 surgical research have been included within the meta-analysis. The authors discovered no variations in self-reported ache or operate between members receiving surgical procedure with or with out PRP. The sufferers that acquired PRP and surgical procedure had a retear charge of ~7%, whereas the management group had a retear charge of ~14%.


PRP could also be an efficient remedy with rotator cuff surgical procedure to scale back the chance of a retear in contrast with surgical procedure with out PRP. Curiously, the PRP failed to supply higher self-reported ache or capabilities than surgical procedure alone. Sadly, it stays unclear whether or not PRP decreases ache and will increase operate in conservatively managed folks. When a clinician seems on the numerous trials amongst folks conservatively managed, the clinician wants to contemplate what the opposite remedy group acquired, the PRP protocol, and the follow-up visits. Clinicians ought to concentrate on the trials that replicate their PRP protocol (or what they’ll supply) and affected person inhabitants in addition to contemplate whether or not they wish to see how their outcomes examine to traditional care, placebo, or an lively intervention (e.g., corticosteroid). Lastly, it’s price remembering to concentrate on variations between teams in a scientific trial. This comparability is the one one which takes benefit of why we wish to randomize folks into totally different teams. Outcomes that look at adjustments over time inside a gaggle could also be influenced by placebo results, regression to the imply, or different components unrelated to the remedy.

Scientific Implications

The usage of PRP might lower the chance of retear if carried out together with surgical procedure. If a affected person is receiving conservative administration, clinicians can search for particular research that simulate their follow and remedy targets to assist sufferers determine. Nevertheless, sufferers receiving conservative care also needs to perceive that the proof for PRP is murky, however the danger of antagonistic occasions is low.   

Questions for Dialogue

Have any of your sufferers acquired PRP injections? In that case, what have been their ideas? Would you employ or advocate PRP remedy?

Associated Posts

  1. Widespread Medicines Might Impression PRP Efficacy
  2. The Constructive Results of Totally different Platelet-Wealthy Plasma Strategies on Human Muscle, Bone, and Tendon Cells
  3. Platelet-Wealthy Plasma Falls Brief In contrast with Train Remedy

Written by Jane McDevitt
Reviewed by Jeffrey Driban

Upper Extremity EBP CEU Course

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